For instance, If the radio was programed once using a version 03.01.00 your CPS wont read the radio. If you use a newer CPS to program a radio, you must always use that CPS or newer, you cant roll back to a previous version. Motorola isnt like other radio softwares. This should give you the proper com port you need.
To figure out which com port you need, go to device manager and look under USB Controllers. I suspect you have the wrong com port selected. Using USB cables usually puts you around com port 3 or 4, not 1. Most likely cause that I see is that you have com port 1 selected.
First, make sure the radio is on (I know its a given if you have programmed radios previously but sometimes people forget)